Role of Matrix Metalloproteinase in the Progression of Heart Failure: A Narrative Review

Heart failure (HF) is a cardiovascular disease with complex pathological pathway and influenced by many factors. Such mechanism would impair cardiac function structural stability. One that plays role in maintaining the structure of heart extracellular matrix (ECM), disruption has causing dysfunction. ECM regulation associated metalloproteinase (MMP). Overexpression metalloproteinases can lead to degradation process which leads remodelling. The MMP also related increased inflammatory response, one pathways for progression failure. close association development makes potential biological marker. This article aims was understand its mechanisms remodelling leading narrative review suggests overexpression Inflammation factors triggering expression MMP. will increase release pro-inflammatory cytokines, thereby expression. imbalance damage collagen tissue through heart. be used as marker cases. application assess degree severity well predictor In conclusion, an important cases